Authors
P Maier
B Saad
HP Schawalder
Pages From
423
Pages To
435
Journal Name
Toxicology in vitro
Volume
8
Issue
3
Abstract

The influence of periportal-and centrilobular-equivalent oxygen tensions on cellular
functions and xenobiotic metabolism was investigated in rat hepatocytes cultured under
20%(air/CO 2), 13% or 4% O 2 for up to 9 days on teflon membrane dishes, coated with
crude membrane fractions and collagen. Protein content, total cytochrome P-450 content, 7-
ethoxy-resorufin-O-deethylase (EROD) and the profile of hydroxytestosterone metabolites
were not significantly affected by the oxygen tension, whereas intracellular lactate ...