Due to interruptions in the learning process at different universities in Palestine either because of the political situtaation or the COVID-19 pandemic, distance learning is becoming an adopted approach during academic semesters in disaster management planning for such universities. Consequently, different Learning Management Systems (LMS) are supporting synchronous and asynchronous teaching modalities. However, distance learning has some obstacles for nursing students who need to acquire skills taught in a real nursing laboratories. Among the possible solutions that can alleviate such an issue is virtual reality (VR) technology. This study aims at analyzing and designing a VR system (NursingXR) that provides training and assessments to nursing students of fundamentals of nursing lab courses in their undergraduate programs. The study presents a hybrid approach which utilizes the Multimedia Development Life Cycle (MDLC) along with Hierarchical Task Analysis (HTA) and Unified Modeling Language (UML) diagrams. The outcome is then used to provide the necessary information to VR developers in the implementation phase of the project. To validate the proposed requirements and HTA and UML diagrams, a prototype was developed based on output from analysis, design, and data collection phases. Results showed that the proposed hybrid approach is valid to develop VR applications in the medical domain.