Authors
Ibrahaim Abu-Shqair
Nizam Diab
Radi Salim
Mohammad Al-Subu
Pages From
179
Pages To
184
Journal Name
Asian Journal of Applied Sciences
Volume
1
Issue
5
Keywords
fluoroquinolone , DNA binding, Intercalation, UV - Visible Methods
Abstract
UV-visible spectroscopic methods were used to study the interaction of some fluoroquinolones with calf-thymus DNA. The binding constants of drug-DNA complexes were evaluated and the nature of binding of these drugs with DNA were elucidated. The results suggested that fluoroquinolones bind to DNA through an electrostatic mode of interaction with partial intercalation.