This paper aims to understand the mediating role of general self-efficacy (GSE) in the effect of environment supports (work and none work environments) on individual creativity in Palestinian small and medium enterprises (SMEs). Respondents for this paper are 247 of employees and owners in SMEs in North West Bank - Palestine. The findings show that work and non-work environments are significantly directly influenced on GSE, while, not directly influenced individual creativity. In addition, the results show that GSE plays a significant mediating role in enhancing the effect of environment supports on individual creativity in the Palestinian SMEs