The study focused on using the techniques of (Whole Exome Sequencing) to identify the skin cancer-causing mutations in a Palestinian family. The findings revealed a genetic mutation "ERCC2 (p.R683Q)" which was inherited in the family, which may be responsible for causing the skin cancer. The study sheds light on the importance of studying genetic mutations of cancer patients and their families in Palestine to guide the diagnosis and management for patients and their families.