This study aims to identify irritable bowel syndrome, depression, anxiety, and stress as well as the relationship between them among Palestinian university students. The researcher used a cross-sectional quantitative analytical design, for a sample of 372 university students from 13 faculties at the Arab American University in Palestine, and they filled out a self-questionnaire containing the Rome 4 criteria for diagnosing irritable bowel syndrome, and a depression, anxiety, and depression scale tool.